Delta, Apple, GlaxoSmithKline, Biogen, and Puma Biotechnology are big market movers

Stocks that moved substantially or traded heavily Wednesday on the New York Stock Exchange and the Nasdaq Stock Market:

NYSE

Delta Air Lines Inc., up $1.47 to $39.15

The airline's second-quarter earnings topped analysts' expectations, as passengers flew more miles at higher average fares and fuel spending declined.

GlaxoSmithKline Plc., down $3.18 to $50.04

The drug developer cut its full-year earnings forcast after reporting a decline in quarterly profit, partly on lower sales.

Puma Biotechnology Inc., up $174.40 to $223.43

The biotechnology company reported positive results from a key late-stage study of a potential breast-cancer treatment.

Nasdaq

Apple Inc., up $2.47 to $97.19

The technology company said quarterly profit rose at its highest rate in two years as shipments of iPhones jumped 13 percent.

Xilinx Inc., down $6.89 to $41.26

The technology company reported lower-than-expected revenue and set its revenue guidance below Wall Street expectations.

Biogen Idec Inc., up $33.93 to $337.60

The biotechnology company's financial results topped expectations on multiple sclerosis drug sales and it boosted its guidance.

Intuitive Surgical Inc., up $69.47 to $461.63

The maker of surgical systems and devices reported a drop in quarterly profit, but the results topped Wall Street expectations.