Markets Right Now: US indexes open mostly lower

The latest on developments in financial markets (All times local):

9:35 a.m.

Big drops in several health care companies are taking stock indexes lower in early trading on Wall Street.

Drugmaker Eli Lilly plunged 14 percent early Wednesday after it said a potential treatment for Alzheimer's disease failed in a clinical trial.

Other health care stocks also fell. Biogen slumped 6 percent.

Agricultural equipment maker Deere & Co. soared 8 percent after reporting strong results for its latest quarter.

The Dow Jones industrial average slipped 4 points, less than 0.1 percent, to 19,019. The Standard & Poor's 500 index fell 5 points, or 0.5 percent, to 2,197. The Nasdaq composite declined 29 points, or 0.5 percent, to 5,357.

U.S. markets will be closed Thursday for Thanksgiving.